As a result of the serious gamble of possible mischief or passing from self-infusing SUBLOCADE into a vein (intravenously), it is just accessible through a limited program called the SUBLOCADE REMS Program.

• SUBLOCADE is not available in retail pharmacies.
• Your SUBLOCADE injection will only be given to you by a certified healthcare provider.

Buprenorphine, an opioid, is in SUBLOCADE. If you take or use certain other medications, it can cause serious and potentially fatal breathing issues.

Converse with your medical care supplier about naloxone, a medication accessible to patients for crisis therapy of a narcotic excess. To treat an opioid overdose or accidental use, you must immediately call 911 or seek emergency medical assistance if naloxone is administered.

SUBLOCADE might cause serious and life‐threatening breathing issues. Immediately seek emergency assistance if you:

• feel faint
• feel dizzy
• are confused
• feel sleepy or uncoordinated
• have blurred vision
• have slurred speech
• are breathing slower than normal
• cannot think well or clearly

Try not to take specific prescriptions during treatment with SUBLOCADE. Taking other narcotic prescriptions, benzodiazepines, liquor, or other focal sensory system depressants (counting road drugs) while on SUBLOCADE can cause serious sleepiness, diminished mindfulness, breathing issues, unconsciousness, and passing.

• In an emergency, have family members tell emergency department staff that you are physically dependent on an opioid and are being treated with SUBLOCADE.
• You may have detectable levels of SUBLOCADE in your body for a long period after stopping treatment with SUBLOCADE.

Death has been reported in those who are not opioid dependent who received buprenorphine sublingually.

Who should not take SUBLOCADE?

If you are allergic to buprenorphine or any of the ingredients in the prefilled syringe (ATRIGEL® Delivery System, a 50:50 biodegradable poly(DL-lactide-co-glycolide) polymer and a biocompatible solvent, N-methyl-2-pyrrolidone (NMP), you should not use SUBLOCADE.

Prior to beginning SUBLOCADE, educate your medical services supplier regarding the entirety of your ailments, including assuming you have:

• trouble breathing or lung problems
• a curve in your spine that affects your breathing
• Addison’s disease
• an enlarged prostate gland (men)
• problems urinating
• liver, kidney, or gallbladder problems
• alcoholism
• a head injury or brain problem
• mental health problems
• adrenal gland or thyroid gland problems

Tell your Healthcare Provider If You Are:

• pregnant or planning to conceive. Narcotic ward ladies on buprenorphine upkeep treatment might require extra absense of pain during work. If you take SUBLOCADE while you are pregnant, your unborn child may experience opioid withdrawal symptoms that could be fatal if they are not treated.
• planning to breastfeed or breastfeeding. It is possible for SUBLOCADE to enter your breast milk and harm your baby. Consult with your medical services supplier about the most ideal way to take care of your child during therapy with SUBLOCADE. Screen your child for expanded sluggishness and breathing issues.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins and herbal supplements.

What should I avoid while being treated with SUBLOCADE?

Until you understand how SUBLOCADE affects you, do not drive, operate heavy machinery, or engage in any other potentially hazardous activity. Buprenorphine can make you sleepy and make it take longer to react. SUBLOCADE can make you sleepy, nauseous, or lightheaded. In the first few days following an injection and when the dose is changed, this may occur more frequently.
During treatment with SUBLOCADE, you should not consume alcohol or take alcohol-containing prescription or over-the-counter medications because doing so could result in unconsciousness or even death.

What are the possible side effects of SUBLOCADE?

SUBLOCADE can cause serious side effects, including:

• Trouble breathing: Taking other opioid medicines, benzodiazepines, alcohol, or other central nervous system depressants during treatment with SUBLOCADE can cause breathing problems that can lead to coma and death.
• Sleepiness, dizziness, and problems with coordination.
• Physical dependence.
• Liver problems: Call your healthcare provider right away if you notice any of these symptoms:
• your skin or the white part of your eyes turns yellow (jaundice)
• dark or “tea-colored” urine
• light colored stools (bowel movements)
• loss of appetite
• pain, aching, or tenderness on the right side of your stomach area
• nausea
• Your healthcare provider should do blood tests to check your liver before you start and during treatment with SUBLOCADE.
• Allergic reaction: You may have a rash, hives, swelling of your face, wheezing, low blood pressure, or loss of consciousness. Call your healthcare provider or get emergency help right away.
• Opioid withdrawal: Call your healthcare provider right away if you get any of these symptoms:
• shaking
• sweating more than normal
• feeling hot or cold more than normal
• runny nose
• watery eyes
• goose bumps
• diarrhea
• vomiting
• muscle aches
• Decrease in blood pressure: You may feel dizzy when you get up from sitting or lying down.

The most common side effects of SUBLOCADE include:

• constipation
• headache
• nausea
• injection site itching
• vomiting
• increase in liver enzymes
• tiredness
• injection site pain

Until you understand how SUBLOCADE affects you, do not drive, operate heavy machinery, or engage in any other potentially hazardous activity. Buprenorphine can make you sleepy and make it take longer to react. SUBLOCADE can make you sleepy, nauseous, or lightheaded. In the first few days following an injection and when the dose is changed, this may occur more frequently.
During treatment with SUBLOCADE, you should not consume alcohol or take alcohol-containing prescription or over-the-counter medications because doing so could result in unconsciousness or even death.

SUBLOCADE might influence ripeness in guys and females. Converse with your medical care supplier in the event that this is a worry for you.

These are not every one of the conceivable aftereffects. For medical advice about side effects, call your doctor.

These are not every one of the conceivable secondary effects. Call your medical services supplier for clinical counsel about incidental effects.